秒速时时彩开奖直播

 
材料与化学化工学部:Characterization of Complex PLGA Formulations

报告题目: Characterization of Complex PLGA Formulations

: 20191119星期二下午16:00-17:30

地点: 独墅湖校区912号楼730


Kinam Park教授简介

Professor Kinam Park received his Ph.D. degree in pharmaceutics from the University of Wisconsin in 1983.  After postdoctoral training at the Department of Chemical Engineering of the same university, he joined the faculty of Purdue University in 1986. Since 1998, he has held a joint appointment in the Department of Biomedical Engineering and became the Showalter Distinguished Professor of Biomedical Engineering in 2006. He has studied drug delivery systems for four decades focusing on the use of polymers for controlled release formulations. His current research focus is PLGA-based injectable, long-acting formulations. He is the founder of Akina, Inc., specializing in specialty polymers used in drug delivery systems and biomedical devices. He also serves as the Editor-in-Chief of the Journal of Controlled Release.


报告摘要:

Poly(lactide-co-glycolide) (PLGA) has been one of the most widely used polymers in pharmaceutical and biomedical fields. The biodegradable polymers are ideal for injectable, long-acting formulations, and yet, only about 20 injectable formulations have been developed in the last 30 years. Such a small number of formulations used clinically is largely due to difficulties in preparing PLGA formulations with desired drug release properties with reproducible results.Such difficulties result from the lack of a clear understanding of the experimental parameters that affect the properties of PLGA formulations. The poor understanding is partly due to an incomplete understanding of PLGA polymer itself.

Recently, new methods of characterizing PLGA polymers have been developed.In particular, new assay techniques have made it possible to separate PLGAs based on their lactide:glycolide (L:G) ratios using newly identified semi-solvents for PLGAs.Also, PLGAs with star-shape molecular structures were characterized for their branch numbers per molecule. These new assay methods allow better characterization of complex PLGA formulations, and thus, the comparison of different formulations for their sameness. Currently, new assay techniques are under development to examine the microstructure of PLGA formulations. All these advanced characterization methods will further our understanding of PLGAs and their roles in controlling drug release profiles in various formulations.


(材料与化学化工学部)
苏大概况 教育教学
院部设置 科学研究
组织机构 合作交流
招生就业 公共服务
Copyright 苏州大学 2016, All Rights Reserved

苏州市十梓街1号 组织策划:校长办公室

苏ICP备-10229414  苏公网安备 32050802010530号
推荐使用IE8.0以上浏览器,1440*900以上分辨率访问本网站